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Clinical trial of amitriptyline and fluphenazine in diabetic peripheral neuropathy.

作者信息

Battla H, Silverblatt C W

出版信息

South Med J. 1981 Apr;74(4):417-8. doi: 10.1097/00007611-198104000-00011.

DOI:10.1097/00007611-198104000-00011
PMID:7013087
Abstract

Ten adult insulin-dependent diabetics with symptomatic peripheral neuropathy were treated with amitriptyline alone or in combination with fluphenazine hydrochloride. Nine of the subjects had a good result within 48 to 72 hours. Two patients reacted adversely to the medication. These medications appear effective in treating the discomfort associated with diabetic peripheral neuropathy.

摘要

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The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain.抗精神病药物氟奋乃静可有效逆转神经性疼痛大鼠模型中的机械性异常性疼痛。
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