Davis J L, Lewis S B, Gerich J E, Kaplan R A, Schultz T A, Wallin J D
JAMA. 1977 Nov 21;238(21):2291-2.
The pain of diabetic peripheral neuropathy responds poorly to current modes of treatment. We treated eight patients with this disorder whose pain was refractory to standard regimens but who experienced remarkable pain relief within two to five days after treatment with fluphenazine hydrochloride, amitriptyline hydrochloride, or a combination of the two. In four patients whose regimens were discontinued, pain recurred within two days and again remitted on reinstitution of the drug regimens. These findings suggest that fluphenazine alone or in combination with amitriptyline may be of benefit in treating the painful peripheral neuropathy associated with diabetes.
糖尿病性周围神经病变的疼痛对目前的治疗方式反应不佳。我们治疗了8例患有这种疾病的患者，他们的疼痛对标准治疗方案无效，但在用盐酸氟奋乃静、盐酸阿米替林或两者联合治疗后的两到五天内疼痛得到了显著缓解。在4例停止治疗方案的患者中，疼痛在两天内复发，重新使用药物治疗方案后再次缓解。这些发现表明，单独使用氟奋乃静或与阿米替林联合使用可能有助于治疗与糖尿病相关的疼痛性周围神经病变。
