Solomons N W, Marchini J S, Duarte-Favaro R M, Vannuchi H, Dutra de Oliveira J E
Am J Clin Nutr. 1983 Apr;37(4):566-71. doi: 10.1093/ajcn/37.4.566.
Mineral/mineral interactions at the intestinal level are important in animal nutrition and toxicology, but only limited understanding of their extent or importance in humans has been developed. An inhibitory interaction of dietary tin on zinc retention has been recently described from human metabolic studies. We have explored the tin/zinc interaction using the change-in-plasma-zinc-concentration method with a standard dosage of 12.5 mg of zinc as zinc sulfate in 100 ml of Coca-Cola. Sn/Zn ratios of 2:1, 4:1, and 8:1, constituted by addition of 25, 50, and 100 mg of tin as stannous chloride, had no significant overall effect on zinc uptake. The 100-mg dose of tin produced noxious gastrointestinal symptoms. Addition of iron as ferrous sulfate to form ratios of Sn/Fe/Zn of 1:1:1 and 2:2:1 with the standard zinc solution and the appropriate doses of tin produced a reduction of zinc absorption not dissimilar from that seen previously with zinc and iron alone, and addition of picolinic acid did not influence the uptake of zinc from the solution with the 2:2:1 Sn/Fe/Zn ratio.
矿物质在肠道水平的相互作用在动物营养和毒理学中很重要，但目前人们对其在人类中的程度或重要性了解有限。最近的人体代谢研究表明，膳食中的锡对锌的保留有抑制作用。我们使用血浆锌浓度变化法，以100毫升可口可乐中12.5毫克硫酸锌作为标准锌剂量，探索了锡/锌相互作用。通过添加25毫克、50毫克和100毫克氯化亚锡构成的2:1、4:1和8:1的锡/锌比例，对锌的吸收没有显著的总体影响。100毫克剂量的锡会产生有害的胃肠道症状。向标准锌溶液中添加硫酸亚铁形成1:1:1和2:2:1的锡/铁/锌比例，并加入适当剂量的锡，会使锌的吸收减少，这与之前单独使用锌和铁时的情况没有太大差异，并且添加吡啶甲酸不会影响2:2:1锡/铁/锌比例溶液中锌的吸收。
