曲折的细胞外途径对电阻测量的影响。
Effect of tortuous extracellular pathways on resistance measurements.
作者信息
Mathias R T
出版信息
Biophys J. 1983 Apr;42(1):55-9. doi: 10.1016/S0006-3495(83)84368-9.
Abstract
There are many instances in which we are limited to measuring macroscopic quantities such as a bulk flow or an average field. In biology, wer are frequently interested in using such macroscopic measurements, for example, the total current from a tissue, to determine the microscopic properties of the cells or tubules of the tissue. The microstructure of the tissue will generally increase the resistance to flow over what would be measured in an unstructured medium. This paper derives a fairly general expression for the relationship between effective resistance to macroscopic flow and the specific resistance of the medium conducting the microscopic flow. This expression, called a tortuosity factor, is defined entirely in terms of measurable morphometric and geometric parameters of the tissue.
摘要
在许多情况下，我们只能测量宏观量，如总体流量或平均场。在生物学中，我们常常希望利用此类宏观测量结果，例如组织的总电流，来确定组织中细胞或小管的微观特性。组织的微观结构通常会使流动阻力相较于在非结构化介质中的测量值有所增加。本文推导了一个相当通用的表达式，用于描述宏观流动有效阻力与传导微观流动的介质比电阻之间的关系。这个表达式称为曲折因子，它完全是根据组织可测量的形态测量和几何参数来定义的。
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