Low W C, Lewis P R, Terri S T
Brain Res. 1983 Mar 7;262(2):328-33. doi: 10.1016/0006-8993(83)91028-4.
The ability of embryonic tissue to survive cross-transplantation between histologically incompatible rat strains was examined by transplanting septal neurons from Sprague Dawley fetuses to adult Wistar rats (Ag-B6 to Ag-B2 histocompatibility haplotype). Transplants were found to survive without rejection over a period of 3 months. Furthermore, the laminar pattern of cholinergic innervation was similar to that of homogenic septal transplants and of intrinsic septal projections. These results suggest that embryonic neural tissue transplanted across major histocompatibility barriers are capable of survival for extended periods of time, and are in support of the concept of the privileged nature of embryonic tissue as a source of material for cross-transplantation.
通过将斯普拉格·道利胎儿的中隔神经元移植到成年Wistar大鼠（组织相容性单倍型从Ag - B6到Ag - B2），研究了胚胎组织在组织学不相容的大鼠品系间进行交叉移植时的存活能力。发现移植组织在3个月的时间内未被排斥而存活。此外，胆碱能神经支配的层状模式与同基因中隔移植以及中隔内源性投射的模式相似。这些结果表明，跨越主要组织相容性屏障移植的胚胎神经组织能够长时间存活，这支持了胚胎组织作为交叉移植材料来源具有特殊性质的概念。
