Weisner B, Roethig H J
Eur Neurol. 1983;22(2):96-105. doi: 10.1159/000115544.
Prealbumin, was determined in serum, lumbar and ventricular cerebrospinal fluid (CSF) and compared with albumin and IgG. The measured concentrations of prealbumin in the CSF indicate that there are two sources of prealbumin: a minor fraction enters the CSF via the blood-cerebrospinal fluid (B-CSF) barrier like albumin, and the major fraction enters the CSF at the ventricles, probably during production of the CSF in the ventricles. The two fractions can be calculated from the CSF concentration of prealbumin, serum prealbumin and the concentration gradient (serum/CSF) of albumin. The B-CSF barrier-independent prealbumin can be used as an indicator of CSF circulation. This was proved by the investigation of several special cases.
检测了血清、腰椎和脑室脑脊液（CSF）中的前白蛋白，并与白蛋白和IgG进行了比较。脑脊液中前白蛋白的测量浓度表明，前白蛋白有两个来源：一小部分像白蛋白一样通过血脑屏障（B-CSF）进入脑脊液，而大部分在脑室进入脑脊液，可能是在脑室脑脊液产生过程中。这两部分可以根据脑脊液中前白蛋白的浓度、血清前白蛋白以及白蛋白的浓度梯度（血清/脑脊液）来计算。不依赖血脑屏障的前白蛋白可作为脑脊液循环的指标。这在几个特殊病例的研究中得到了证实。
