Kanel G C, Radvan G, Peters R L
Hepatology. 1983 May-Jun;3(3):343-8. doi: 10.1002/hep.1840030311.
To establish whether there is any significant relationship between high-density lipoprotein cholesterol (HDLC) concentrations and biopsy-documented liver disease, 169 patients had needle biopsies, serum cholesterol, and HDLC evaluated. Twenty-four patients had serial cholesterol, HDLC, prothrombin, and aminotransferase levels and activities examined. In both men and women, HDLC decreased strikingly and significantly in acute alcoholic hepatitis and in acute viral hepatitis, compared to controls (p less than 0.001). Men and women with inactive alcoholic liver disease and chronic active hepatitis showed moderate decreased in HDLC (p less than 0.001). Patients with primary and metastatic hepatic neoplasms also had strikingly decreased HDLC (p less than 0.001). Serial testing showed an excellent direct correlation between HDLC and prothrombin activity, r values ranging from 0.71 to 0.98. Although alcohol intake is known to correlate positively with HDLC concentrations, our data shows that this association is not absolute, and in most cases is reversed once liver disease becomes apparent.
为确定高密度脂蛋白胆固醇（HDLC）浓度与经活检证实的肝脏疾病之间是否存在任何显著关联，对169例患者进行了针吸活检、血清胆固醇和HDLC评估。对24例患者进行了胆固醇、HDLC、凝血酶原和转氨酶水平及活性的系列检测。与对照组相比，无论是男性还是女性，急性酒精性肝炎和急性病毒性肝炎患者的HDLC均显著降低（p<0.001）。非活动性酒精性肝病和慢性活动性肝炎的男性和女性患者的HDLC中度降低（p<0.001）。原发性和转移性肝肿瘤患者的HDLC也显著降低（p<0.001）。系列检测显示HDLC与凝血酶原活性之间存在极好的直接相关性，r值范围为0.71至0.98。虽然已知酒精摄入量与HDLC浓度呈正相关，但我们的数据表明这种关联并非绝对，而且在大多数情况下，一旦肝病明显，这种关联就会逆转。
