Maciejewski B, Preuss-Bayer G, Trott K R
Int J Radiat Oncol Biol Phys. 1983 Mar;9(3):321-8. doi: 10.1016/0360-3016(83)90290-0.
Three hundred and ten patients with T3/T4, N0, M0 squamous cell carcinoma were irradiated with 200 kV X rays with total doses ranging from 4,900 to 6,200 rad, given in 21 to 35 fractions in 32-63 days. After a minimum follow-up period of 3 years, the local control rate was 50%; 21 severe late complications were observed among the patients. The dependence of local control rate and of late complication rate on the dose per fraction and on overall treatment time was analyzed by various statistical methods. Whereas the late complication rate depended significantly on dose per fraction, local tumor control depended strongly on overall treatment time.
310例T3/T4、N0、M0期鳞状细胞癌患者接受了200 kV X线照射，总剂量为4900至6200拉德，在32至63天内分21至35次给予。经过至少3年的随访期，局部控制率为50%；患者中观察到21例严重晚期并发症。采用多种统计方法分析了局部控制率和晚期并发症率对分次剂量和总治疗时间的依赖性。晚期并发症率显著依赖于分次剂量，而局部肿瘤控制则强烈依赖于总治疗时间。
