Sunakawa K, Akita H, Jozaki K, Iwata S, Iwasaki Y, Sato Y, Tojoh M, Wakabayashi R, Hayano S, Osano M, Matsuo T, Yamada Z, Suzuki H, Ichihashi Y
Jpn J Antibiot. 1983 Jan;36(1):47-54.
Pharmacokinetics of gentamicin in children after intravenous infusion over 60 minutes were compared with that after intramuscular injection. 1. Mean measured peak serum levels after intravenous infusion of 2.5 mg/kg and intramuscular injection of 2.0 mg/kg were 6.1 micrograms/ml at termination of infusion and 6.5 micrograms/ml at 30 or 60 minutes after injection, respectively. Older children showed higher serum levels. 2. There was no difference in serum half-life between both modes of administration. 3. The AUC after intravenous infusion was slightly larger than that after intramuscular injection. 4. It was suggested that the efficacy and safety of the treatment by intravenous infusion in children are comparable to that by the intramuscular injection, and optimum single dose is 1.5--2.5 mg/kg.
将庆大霉素静脉输注60分钟后在儿童体内的药代动力学与肌肉注射后的药代动力学进行了比较。1. 静脉输注2.5mg/kg和肌肉注射2.0mg/kg后，平均实测血清峰值水平在输注结束时分别为6.1微克/毫升，在注射后30或60分钟时分别为6.5微克/毫升。年龄较大的儿童血清水平较高。2. 两种给药方式的血清半衰期无差异。3. 静脉输注后的AUC略大于肌肉注射后的AUC。4. 提示儿童静脉输注治疗的疗效和安全性与肌肉注射相当，最佳单剂量为1.5 - 2.5mg/kg。
