Shiramatsu K, Ishida K, Takahashi K, Kunimoto M, Denno R, Akiyama M, Hirata K, Hayasaka H
Jpn J Antibiot. 1983 Feb;36(2):293-8.
Serum concentrations of gentamicin (GM) were monitored after intravenous drip infusion of 60 mg over 30 minutes, 1 hour and 2 hours. These concentrations were compared with those after intramuscular injection. The mean peak serum concentration obtained at 30 minutes after intramuscular injection (5.09 micrograms/ml) and those obtained at the end of intravenous drip infusion (5.17--6.66 micrograms/ml) were comparable. Serum concentrations decreased to less than 2.0 micrograms/ml at 6 to 8 hours after injection or infusion in all cases except 1 with less body weight than others. Pharmacokinetic analysis showed that the T1/2 of GM ranged from 2.49 to 4.33 hours and that the AUC ranged from 19.66 to 27.09 hr X micrograms/ml. Results obtained in this study suggested that the usefulness of intravenous drip infusion over the time from 30 minutes to 2 hours is equal to that of intramuscular injection in the GM therapy.
在30分钟、1小时和2小时内静脉滴注60毫克庆大霉素（GM）后监测血清浓度。将这些浓度与肌肉注射后的浓度进行比较。肌肉注射后30分钟获得的平均血清峰值浓度（5.09微克/毫升）与静脉滴注结束时获得的浓度（5.17 - 6.66微克/毫升）相当。除1例体重比其他患者轻的情况外，所有注射或输注后的血清浓度在6至8小时降至低于2.0微克/毫升。药代动力学分析表明，GM的半衰期为2.49至4.33小时，曲线下面积为19.66至27.09小时×微克/毫升。本研究结果表明，在GM治疗中，30分钟至2小时的静脉滴注效果与肌肉注射相当。
