Halsey M J, Wardley-Smith B
Neuropharmacology. 1983 Jan;22(1):103-8. doi: 10.1016/0028-3908(83)90267-8.
The hypothesis that non-anaesthetic compounds, structurally related to specific anaesthetics, can protect against the high pressure neurological syndrome was tested. Infusion of two structural analogues of alphaxalone (3 alpha-hydroxy-5 alpha pregnane-11,20 dione) during pressurisation of rats with helium and oxygen gas mixtures (total pressure 80-100 ATA; inspired oxygen partial pressure 0.5 ATA) ameliorated the severe tremors associated with the high pressure neurological syndrome without any shift in tremor frequency (11-14 Hz). The steroid analogues which were selected (delta 16 and 3 beta-hydroxy-alphaxalone) have no known general anaesthetic effects and present an unexpected structural approach to the pharmacology of the syndrome. It may now be possible to investigate, treat or prevent the syndrome by the use of selective drugs without more generalised anaesthetic effects.
与特定麻醉剂结构相关的非麻醉化合物可预防高压神经综合征。在用氦气和氧气混合气体（总压80 - 100ATA；吸入氧分压0.5ATA）对大鼠加压过程中，输注两种α-羟孕酮（3α-羟基-5α-孕烷-11,20-二酮）的结构类似物，可改善与高压神经综合征相关的严重震颤，且震颤频率（11 - 14Hz）无任何变化。所选的类固醇类似物（δ16和3β-羟基-α-羟孕酮）无已知的全身麻醉作用，为该综合征的药理学提供了一种意想不到的结构研究方法。现在或许有可能通过使用无更广泛麻醉作用的选择性药物来研究、治疗或预防该综合征。
