Grande F
Prev Med. 1983 Jan;12(1):110-4. doi: 10.1016/0091-7435(83)90178-0.
Numerous controlled dietary experiments in various U.S. laboratories have demonstrated that fatty acid composition and cholesterol content of the diet influence human serum cholesterol concentration. Work in Ancel Keys's (1) laboratory has shown that the serum cholesterol changes produced by controlled dietary modifications in middle-aged, metabolically normal male subjects in energy balance can be predicted from changes in fatty acid composition and cholesterol content of the diet. The serum cholesterol changes are mostly accounted for by those of low-density lipoprotein cholesterol. The results of some of the European studies are generally comparable to those obtained in Minnesota. Thus, the results in one of the Finnish Hospital studies are in perfect agreement with the prediction of the Keys, Anderson, and Grande equation: good agreement has also been found with the results of a recent experiment by Schlierf et al. in Heidelberg. The effects of dietary cholesterol observed by Dutch workers are also in agreement with our prediction, when cholesterol (egg yolk) was added to a diet rich in polyunsaturated fatty acids, but not when added to a diet rich in saturated fatty acids.
美国各实验室进行的大量对照饮食实验表明，饮食中的脂肪酸组成和胆固醇含量会影响人体血清胆固醇浓度。安塞尔·基斯（1）实验室的研究表明，在能量平衡状态下，对中年、代谢正常的男性受试者进行对照饮食调整所引起的血清胆固醇变化，可以根据饮食中脂肪酸组成和胆固醇含量的变化来预测。血清胆固醇的变化主要由低密度脂蛋白胆固醇的变化引起。一些欧洲研究的结果与在明尼苏达州获得的结果总体相当。因此，芬兰医院的一项研究结果与基斯、安德森和格兰德方程的预测完全一致：与施利尔夫等人最近在海德堡进行的实验结果也吻合良好。荷兰研究人员观察到的饮食胆固醇的影响也与我们的预测相符，即在富含多不饱和脂肪酸的饮食中添加胆固醇（蛋黄）时，但在富含饱和脂肪酸的饮食中添加时则不然。
