Kanarek R B, Collier G H
Physiol Behav. 1983 Feb;30(2):307-11. doi: 10.1016/0031-9384(83)90024-0.
Rats housed in either activity wheels or standard laboratory cages received access to food either ad lib or for one 60-min, two 30-min, or four 15-min periods per day. Imposition of restricted feeding schedules led to reductions in food intake and body weight which were greater for animals with access to activity wheels. Increases in activity reflected the percent of body weight loss, which varied directly with frequency of food access. Subsequent recovery of intake was facilitated by partitioning total feeding time into briefer but more frequent periods. In the most extreme frequency-of-access condition, animals with access to running wheels failed to recover from the reduction of intake incurred by imposition of the restricted feeding schedule, even though their total feeding time was the same as that of animals that did recover. These data indicate that self-starvation is not induced by activity per se but results from a general failure to recover intake which, in turn, results from a failure to override the satiety signal within a meal.
饲养在活动轮或标准实验室笼子里的大鼠，可随意进食或每天在一个60分钟、两个30分钟或四个15分钟的时间段内进食。实施限制进食时间表会导致食物摄入量和体重下降，对于能使用活动轮的动物来说下降幅度更大。活动增加反映了体重减轻的百分比，体重减轻百分比与进食频率直接相关。将总进食时间分成更短但更频繁的时间段有助于随后摄入量的恢复。在最极端的进食频率条件下，即使能使用活动轮的动物的总进食时间与能够恢复的动物相同，但它们仍未能从因实施限制进食时间表而导致的摄入量减少中恢复过来。这些数据表明，自我饥饿不是由活动本身引起的，而是由于无法恢复摄入量这一普遍问题导致的，而无法恢复摄入量又是由于无法在一餐中克服饱腹感信号所致。
