Luoma H, Aromaa A, Helminen S, Murtomaa H, Kiviluoto L, Punsar S, Knekt P
Acta Med Scand. 1983;213(3):171-6. doi: 10.1111/j.0954-6820.1983.tb03712.x.
To study the influence of drinking water composition on the risk of myocardial infarction, the following study was conducted: The cases (C), men 30-64 years of age, had been discharged with a first acute myocardial infarction (AMI) from Kotka Central Hospital. The hospital controls (HC), matched for age and type of community, were selected for each case among surgical patients. Population controls (PC), matched for age and municipality, were drawn for each case from the population register. Subjects submitted a sample of their drinking water and a filled-in questionnaire. After exclusions, a series of 50 C-HC and 50 C-PC pairs was finally constructed. The point estimate of relative risk (RR) for the association between low F (less than or equal to 0.1 ppm) and increased risk of AMI was 3.0 in the C-HC series. In the C-PC comparison, RR was 4.4 RR for low Mg (less than or equal to 1.2 ppm) was 2.0 in the C-HC comparison and 4.7 in the C-PC comparison. The results are consistent with the hypothesis that both a low F and a low Mg intake are conducive to atherosclerosis leading to AMI.
为研究饮用水成分对心肌梗死风险的影响，进行了以下研究：病例组（C）为年龄在30 - 64岁之间因首次急性心肌梗死（AMI）从科特卡中心医院出院的男性。医院对照组（HC）为从外科手术患者中为每个病例匹配年龄和社区类型选取的对象。人群对照组（PC）为从人口登记册中为每个病例匹配年龄和直辖市选取的对象。研究对象提交了一份其饮用水样本和一份填写好的问卷。经过排除后，最终构建了一系列50对C - HC和50对C - PC配对。在C - HC系列中，低氟（小于或等于0.1 ppm）与AMI风险增加之间关联的相对风险（RR）点估计值为3.0。在C - PC比较中，低镁（小于或等于1.2 ppm）的RR在C - HC比较中为2.0，在C - PC比较中为4.7。结果与低氟和低镁摄入均有利于导致AMI的动脉粥样硬化这一假设一致。
