牛源色氨酸转运RNA（tRNATrp）与禽成髓细胞瘤病毒逆转录酶结合并作为异源引物发挥作用。
tRNATrp (bovine) binding to the reverse transcriptase of avian myeloblastosis virus and function as a heterologous primer.
作者信息
Baroudy B M, Fournier M, Labouesse J, Papas T S, Chirikjian J G
出版信息
Proc Natl Acad Sci U S A. 1977 May;74(5):1889-93. doi: 10.1073/pnas.74.5.1889.
Abstract
The primary structures for tTNATrp (bovine) and primer tRNATrp (avian) show only minor differences in nucleotide sequence. The heterologous tRNATrp (bovine) appears to have properties similar to the tRNATrp (avian) in its ability to bind the alphabeta from of RNA-dependent DNA nucleotidyltransferase of avian myeloblastosis virus. A stable enzyme-tRNA complex has been isolated by gel filtration. In addition, tRNATrp (bovine) can hydridize to the avian viral 35S RNA and act as a primer for transcription of the RNA. tRNATrp (bovine) can be obtained in larger amounts than the avian primer and can be used to study the interactions between the primer and the viral enzyme.
摘要
tTNATrp（牛源）和引物tRNATrp（禽源）的一级结构在核苷酸序列上仅显示出微小差异。异源tRNATrp（牛源）在结合禽成髓细胞瘤病毒的RNA依赖性DNA核苷酸转移酶的αβ形式的能力方面，似乎具有与tRNATrp（禽源）相似的特性。通过凝胶过滤分离出了一种稳定的酶 - tRNA复合物。此外，tRNATrp（牛源）可以与禽病毒35S RNA杂交，并作为RNA转录的引物。与禽源引物相比，tRNATrp（牛源）可以大量获得，可用于研究引物与病毒酶之间的相互作用。
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tRNATrp (bovine) binding to the reverse transcriptase of avian myeloblastosis virus and function as a heterologous primer.牛源色氨酸转运RNA（tRNATrp）与禽成髓细胞瘤病毒逆转录酶结合并作为异源引物发挥作用。
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