禽成髓细胞瘤逆转录酶使色氨酰 - tRNA脱酰基。
Avian myeloblastosis reverse transcriptase deacylates tryptophanyl-tRNA.
作者信息
Sarih L, Fournier M, von der Haar F, Labouesse J, Litvak S
出版信息
Nucleic Acids Res. 1982 Nov 25;10(22):7387-93. doi: 10.1093/nar/10.22.7387.
Abstract
Tryptophanyl-tRNA can be used as a primer for RNA-dependent DNA synthesis by avian reverse transcriptase. We have determined that whereas the retroviral polymerase is not by itself capable of deacylating Trp-tRNATrp, the ester linkage between the 3' OH of the ribose moiety and the aminoacid can be very efficiently hydrolyzed when both the polymerase and the viral 35 S RNA are present.
摘要
色氨酰 - tRNA可被禽逆转录酶用作依赖RNA的DNA合成的引物。我们已经确定，虽然逆转录病毒聚合酶本身不能使色氨酰 - tRNA去酰化，但当聚合酶和病毒35S RNA都存在时，核糖部分3'羟基与氨基酸之间的酯键可以非常有效地被水解。
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本文引用的文献
1
Photochemical cross-linking studies on the interactions of avian myeloblastosis virus reverse transcriptase with primer tRNATrp and TTP.关于禽成髓细胞瘤病毒逆转录酶与引物tRNATrp和TTP相互作用的光化学交联研究。
Arch Biochem Biophys. 1980 Dec;205(2):437-48. doi: 10.1016/0003-9861(80)90127-7.
2
Reverse transcriptase as the major determinant for selective packaging of tRNA's into Avian sarcoma virus particles.逆转录酶作为tRNA选择性包装进禽肉瘤病毒颗粒的主要决定因素。
J Virol. 1980 Dec;36(3):692-700. doi: 10.1128/JVI.36.3.692-700.1980.
3
Study of the interactions between avian myeloblastosis virus reverse transcriptase and primer tRNA. Affinity labeling and inactivation of the enzyme by periodate-treated tRNATrp.禽成髓细胞瘤病毒逆转录酶与引物tRNA相互作用的研究。经高碘酸盐处理的tRNATrp对该酶的亲和标记及失活作用。
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4
Studies on the mechanism of deacylation of aminoacyl-tRNAs by aminoacyl-tRNA synthetases in the absence of adenosine monophosphate and pyrophosphate.在无磷酸腺苷和焦磷酸情况下，对氨酰-tRNA合成酶催化氨酰-tRNA脱酰基化机制的研究。
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