一组广谱头孢菌素及其他β-内酰胺类抗生素对沙眼衣原体的体外活性
In vitro activity of a group of broad-spectrum cephalosporins and other beta-lactam antibiotics against Chlamydia trachomatis.
作者信息
Hammerschlag M R, Gleyzer A
出版信息
Antimicrob Agents Chemother. 1983 Mar;23(3):493-4. doi: 10.1128/AAC.23.3.493.
Abstract
The activities of seven broad spectrum cephalosporins, four other beta-lactam antibiotics, and one monobactam against Chlamydia trachomatis were measured in a cell culture system. The minimal inhibitory concentration of four of the seven cephalosporins was greater than or equal to 128 micrograms/ml; those of the other three were from 16 to 32 micrograms/ml. Of the other agents, only mecillinam had activity against C. trachomatis comparable to that reported for ampicillin (minimal inhibitory concentration, less than or equal to 0.5 micrograms/ml).
摘要
在细胞培养系统中测定了七种广谱头孢菌素、四种其他β-内酰胺抗生素和一种单环β-内酰胺类药物对沙眼衣原体的活性。七种头孢菌素中有四种的最低抑菌浓度大于或等于128微克/毫升；另外三种的最低抑菌浓度为16至32微克/毫升。在其他药物中，只有美西林对沙眼衣原体的活性与氨苄西林报道的活性相当（最低抑菌浓度小于或等于0.5微克/毫升）。
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