Terrence C F, Fromm G H, Roussan M S
Arch Neurol. 1983 Jan;40(1):28-9. doi: 10.1001/archneur.1983.04050010048011.
Baclofen has been reported to be epileptogenic in man, but many animal studies have demonstrated an anticonvulsant effect. In 12 patients with a history of epilepsy, baclofen was given in the conventional dosage range. In the six patients with anticonvulsant-controlled seizures, none had a seizure during baclofen therapy. In the six patients with uncontrolled epilepsy, two patients had one more seizure per month while receiving baclofen, and a third went from four seizures per month to one per month. Baclofen does not appear to have a deleterious effect in patients with epilepsy.
据报道，巴氯芬在人类中可致癫痫，但许多动物研究已证明其具有抗惊厥作用。在12例有癫痫病史的患者中，给予了常规剂量范围的巴氯芬。在6例惊厥由抗惊厥药物控制的患者中，在巴氯芬治疗期间均未发生惊厥。在6例癫痫未得到控制的患者中，2例在接受巴氯芬治疗时每月发作次数增加1次，第3例从每月发作4次减至每月发作1次。巴氯芬似乎对癫痫患者没有有害影响。
