Urano M, Cunningham M
Cancer Res. 1980 Jan;40(1):26-8.
Effect of pretransplantation hyperthermia of tumor bed on tumor growth was studied. Experimental tumors were isotransplants of a fibrosarcoma which arose spontaneously in C3Hf/Sed mice. The pretransplantation hyperthermia was given at 43.5 degrees fro 120 min by immersing the mouse foot into a constant temperature water bath. This treatment resulted in a similar foot reaction to a single gamma-ray dose of 3500 rads, namely, complete epilation or partial moist desquamation. The pretransplantation hyperthermia failed to retard tumor growth, while the concurrent experiment on pretransplantation irradiation demonstrated marked retardation of tumor growth. No retardation was observed when tumor cells were transplanted into the contralateral untreated feet or into the untreated skin.
研究了肿瘤床移植前高温对肿瘤生长的影响。实验性肿瘤是C3Hf/Sed小鼠自发产生的纤维肉瘤的同基因移植瘤。通过将小鼠足部浸入恒温水浴中，在43.5摄氏度下进行120分钟的移植前高温处理。这种处理导致的足部反应与单次3500拉德γ射线照射相似，即完全脱毛或部分湿性脱屑。移植前高温未能延缓肿瘤生长，而同期进行的移植前照射实验则显示肿瘤生长明显延缓。当将肿瘤细胞移植到对侧未处理的足部或未处理的皮肤中时，未观察到生长延缓。
