17β-雌二醇处理后人精子对无透明带仓鼠卵穿透效率的刺激作用

Stimulation of the zona-free hamster ova penetration efficiency by human spermatozoa after 17 beta-estradiol treatment.

作者信息

Chan S Y, Tang L C, Ma H K

出版信息

Fertil Steril. 1983 Jan;39(1):80-4. doi: 10.1016/s0015-0282(16)46762-2.

Abstract

17 beta-Estradiol (E2) stimulated the zona-free hamster ova penetration by human spermatozoa from both fertile and subfertile men after 5 hours of incubation in vitro. For spermatozoa samples from fertile men, the mean penetration rates increased significantly (P less than 0.05), from 35.6% +/- 3.5% (control) to 60.1% +/- 5.8% (E2 = 50 ng/ ml) and 50.5% +/- 2.6% (E2 = 100 ng/ml), respectively. E2 also increased the mean penetration rates of spermatozoa samples from subfertile men significantly (P less than 0.05), from 10.2% +/- 1.8% (control) to 30.5% +/- 7.2% (E2 = 50 ng/ml) and 33.1% +/- 6.6% (E2 = 100 ng/ml), respectively. These findings indicate that E2 can affect the fertilizing ability of human spermatozoa in vitro.

摘要

在体外孵育5小时后，17β-雌二醇（E2）刺激了来自生育力正常和生育力低下男性的人类精子穿透去透明带仓鼠卵的能力。对于来自生育力正常男性的精子样本，平均穿透率显著增加（P<0.05），分别从35.6%±3.5%（对照组）增至60.1%±5.8%（E2 = 50 ng/ml）和50.5%±2.6%（E2 = 100 ng/ml）。E2也显著增加了来自生育力低下男性的精子样本的平均穿透率（P<0.05），分别从10.2%±1.8%（对照组）增至30.5%±7.2%（E2 = 50 ng/ml）和33.1%±6.6%（E2 = 100 ng/ml）。这些发现表明，E2在体外可影响人类精子的受精能力。