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1
The mediation of tissue eosinophilia in hypersensitivity reactions. IV. Production of delayed eosinophil chemotactic factor-a by peritoneal exudate cells from sensitized guinea-pigs in vitro.超敏反应中组织嗜酸性粒细胞增多的介导作用。IV. 致敏豚鼠腹腔渗出细胞体外产生迟发性嗜酸性粒细胞趋化因子-a
Immunology. 1983 Jan;48(1):69-77.
2
The mediation of tissue eosinophilia in hypersensitivity reactions. III. Separation of two different delayed eosinophil chemotactic factors and transfer of these factors by serum or cells from sensitized guinea-pigs.超敏反应中组织嗜酸性粒细胞增多的介导作用。III. 两种不同的迟发型嗜酸性粒细胞趋化因子的分离以及致敏豚鼠血清或细胞对这些因子的传递
Immunology. 1983 Jan;48(1):59-67.
3
The regulation of tissue eosinophil chemotactic factor and inhibitor in allergic skin lesions of Freund's complete adjuvant-treated guinea-pigs.弗氏完全佐剂处理的豚鼠过敏性皮肤损伤中组织嗜酸性粒细胞趋化因子及抑制剂的调节
Immunology. 1984 Mar;51(3):441-50.
4
Selective regulation of chemotactic lymphokine production. I. Selective potentiation of eosinophil chemotactic lymphokine production in alum hydroxy gel- and Bordetella pertussis vaccine-treated guinea pigs.趋化性淋巴因子产生的选择性调节。I. 明矾羟基凝胶和百日咳博德特氏菌疫苗处理的豚鼠中嗜酸性粒细胞趋化性淋巴因子产生的选择性增强。
J Immunol. 1985 Nov;135(5):3463-7.
5
The mediation of tissue eosinophilia in hypersensitivity reactions. V. Comparative study of tissue eosinophilia in the skin lesions of local and systemic passive cutaneous anaphylactic reactions.超敏反应中组织嗜酸性粒细胞增多的介导作用。V. 局部和全身性被动皮肤过敏反应皮肤损伤中组织嗜酸性粒细胞增多的比较研究。
Immunology. 1983 Sep;50(1):85-91.
6
Eosinophil chemotactic lymphokine produced by spleen cells of Schistosoma japonicum-infected mice. II. Physicochemical heterogeneity of eosinophil chemotactic lymphokines selective to bone marrow- or peritoneal exudate-eosinophils.
Int Arch Allergy Appl Immunol. 1987;83(3):290-5.
7
Regulation of eosinophilia in rats infected with Nippostrongylus brasiliensis. I. Eosinophil chemotactic factor produced spontaneously by mesenteric lymph node cells of infected rats.巴西日圆线虫感染大鼠中嗜酸性粒细胞增多的调节。I. 感染大鼠肠系膜淋巴结细胞自发产生的嗜酸性粒细胞趋化因子。
Int Arch Allergy Appl Immunol. 1984;75(3):264-9.
8
Isolation of an eosinophil chemotactic lymphokine as a natural mediator for eosinophil chemotaxis from concanavalin A-induced skin reaction sites in guinea-pigs.从豚鼠伴刀豆球蛋白A诱导的皮肤反应部位分离出嗜酸性粒细胞趋化性淋巴因子作为嗜酸性粒细胞趋化作用的天然介质。
Clin Exp Immunol. 1984 Jul;57(1):211-9.
9
The mediation of tissue eosinophilia in hypersensitivity reactions. II. Separation of a delayed eosinophil chemotactic factor from macrophage chemotactic factors.超敏反应中组织嗜酸性粒细胞增多的介导作用。II. 从巨噬细胞趋化因子中分离出一种迟发型嗜酸性粒细胞趋化因子。
Immunology. 1976 Aug;31(2):263-71.
10
The regulation of tissue eosinophilia. III. In vitro production of eosinophil-directed chemotactic inhibitory factor by T lymphocytes of complete Freund's adjuvant-treated guinea-pigs.组织嗜酸性粒细胞增多症的调节。III. 完全弗氏佐剂处理的豚鼠T淋巴细胞体外产生嗜酸性粒细胞趋化抑制因子。
Immunology. 1985 May;55(1):115-24.

引用本文的文献

1
Isolation of an eosinophil chemotactic lymphokine as a natural mediator for eosinophil chemotaxis from concanavalin A-induced skin reaction sites in guinea-pigs.从豚鼠伴刀豆球蛋白A诱导的皮肤反应部位分离出嗜酸性粒细胞趋化性淋巴因子作为嗜酸性粒细胞趋化作用的天然介质。
Clin Exp Immunol. 1984 Jul;57(1):211-9.

本文引用的文献

1
Suppression of antibody-mediated accumulation of eosinophils in chronic inflammatory lesions by concomitant delayed hypersensitivity reactions.伴随迟发型超敏反应对慢性炎症病变中抗体介导的嗜酸性粒细胞聚集的抑制作用。
Immunology. 1980 Dec;41(4):981-8.
2
Lymphokine-mediated stimulation of eosinophil migration in the guinea-pig.淋巴因子介导的豚鼠嗜酸性粒细胞迁移刺激作用。
Immunology. 1981 Nov;44(3):481-8.
3
Regulatory role of IgE-binding factors from rat T lymphocytes. V. formation of IgE-potentiating factor by T lymphocytes from rats treated with Bordetella pertussis vaccine.大鼠T淋巴细胞来源的IgE结合因子的调节作用。V. 经百日咳疫苗处理的大鼠T淋巴细胞产生IgE增强因子。
J Immunol. 1981 Mar;126(3):838-42.
4
Regulatory role of IgE-binding factors from rat T lymphocytes. IV. Formation of IgE-binding factors in rats treated with complete Freund's adjuvant.大鼠T淋巴细胞来源的IgE结合因子的调节作用。IV. 用完全弗氏佐剂处理的大鼠中IgE结合因子的形成。
J Immunol. 1980 Nov;125(5):2154-60.
5
The peritoneal exudate lymphocyte. I. Differences in antigen responsiveness between peritoneal exudate and lymph node lymphocytes from immunized guinea pigs.腹膜渗出淋巴细胞。I. 免疫豚鼠腹膜渗出淋巴细胞与淋巴结淋巴细胞抗原反应性的差异。
J Exp Med. 1971 Nov 1;134(5):1170-86. doi: 10.1084/jem.134.5.1170.
6
In vitro and in vivo activity of a lymphocyte and immune complex-dependent chemotactic factor for eosinophils.一种嗜酸性粒细胞的淋巴细胞及免疫复合物依赖性趋化因子的体外和体内活性
J Exp Med. 1971 Jan 1;133(1):133-46. doi: 10.1084/jem.133.1.133.
7
Studies on eosinophil leucocyte migration. II. Factors specifically chemotactic for eosinophils and neutrophils generated from guinea-pig serum by antigen-antibody complexes.嗜酸性白细胞迁移的研究。II. 抗原抗体复合物从豚鼠血清中产生的对嗜酸性粒细胞和中性粒细胞具有特异性趋化作用的因子。
Clin Exp Immunol. 1970 Nov;7(5):723-37.
8
Eosinophils and immune mechanisms. Eosinophil stimulation promoter (ESP): a lymphokine induced by specific antigen or phytohemagglutinin.嗜酸性粒细胞与免疫机制。嗜酸性粒细胞刺激促进因子（ESP）：一种由特异性抗原或植物血凝素诱导产生的淋巴因子。
J Immunol. 1973 May;110(5):1419-23.
9
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
10
On the relation of products of activated lymphocytes to cell-mediated cytolysis.关于活化淋巴细胞产物与细胞介导的细胞溶解作用的关系
J Exp Med. 1974 Sep 1;140(3):837-52. doi: 10.1084/jem.140.3.837.

超敏反应中组织嗜酸性粒细胞增多的介导作用。IV. 致敏豚鼠腹腔渗出细胞体外产生迟发性嗜酸性粒细胞趋化因子-a

The mediation of tissue eosinophilia in hypersensitivity reactions. IV. Production of delayed eosinophil chemotactic factor-a by peritoneal exudate cells from sensitized guinea-pigs in vitro.

作者信息

Hirashima M, Hirotsu Y, Hayashi H

出版信息

Immunology. 1983 Jan;48(1):69-77.

PMID:6848455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454007/
Abstract

An eosinophil chemotactic factor (ECF) was produced in the cell-free culture supernatants (CFS) of peritoneal exudate cells (PEC) from guinea-pigs immunized with dinitrophenyl derivatives of ascaris extract (DNP-As), when stimulated by the antigen in vitro without activation by immune complexes. A 2 or 6 hr pulse of the antigen was sufficient for ECF production, whereas long time incubation (48 hr) was required for the production of a sufficient amount of the factor. Treatment of PEC by cycloheximide resulted in the reduction of ECF production, suggesting that protein synthesis is essential. Its generation appeared carrier-specific and the source of the factor is presumed to be lymphocytes, probably T lymphocyte. The factor with a molecular weight of 70,000 shared a common antigenicity with delayed eosinophil chemotactic factor-a (delayed ECF-a), which was isolated from the skin lesions showing delayed tissue eosinophilia in vivo.

摘要

用蛔虫提取物的二硝基苯基衍生物（DNP-As）免疫的豚鼠腹腔渗出细胞（PEC）的无细胞培养上清液（CFS）中，在无免疫复合物激活的情况下经体外抗原刺激可产生嗜酸性粒细胞趋化因子（ECF）。抗原刺激2或6小时足以产生ECF，而产生足够量的该因子则需要长时间孵育（48小时）。用放线菌酮处理PEC会导致ECF产生减少，表明蛋白质合成至关重要。其产生似乎具有载体特异性，该因子的来源推测为淋巴细胞，可能是T淋巴细胞。分子量为70,000的该因子与从体内显示迟发性组织嗜酸性粒细胞增多的皮肤病变中分离出的迟发性嗜酸性粒细胞趋化因子-a（迟发性ECF-a）具有共同抗原性。