Garza C, Johnson C A, Smith E O, Nichols B L
Am J Clin Nutr. 1983 Jan;37(1):61-5. doi: 10.1093/ajcn/37.1.61.
Six lactating women were recruited at 5 to 7 months postpartum for a study of milk composition during gradual weaning. At recruitment all subjects were exclusively breast-feeding their infants. The subjects were asked to reduce the frequency or duration of breast-feeding episodes by approximately one-third each month for a period of 3 months. Milk was collected before weaning began and at 2-wk intervals for 12 wk. The concentrations of protein and Na were 142 and 220% of base-line values, respectively, at the end of this period. Changes in fat composition were difficult to interpret. A linear trend was observed through wk 10, but values for wk 12 were similar to those obtained before weaning was initiated. The concentration of Fe at wk 12 was 172% of the base-line value. The concentration of Ca did not change and that of Zn fell to 58% of the base-line value at wk 12. The significance of the changes in nutrient concentrations, their relationship to the involution of the mammary gland, and the suitability of milk from this stage of lactation for milk banking are evaluated.
招募了6名产后5至7个月的哺乳期妇女，以研究逐渐断奶期间的乳汁成分。招募时，所有受试者均为纯母乳喂养婴儿。要求受试者在3个月的时间内，每月将母乳喂养的频率或时长减少约三分之一。在断奶开始前以及之后的12周内，每隔2周采集一次乳汁。在此期间结束时，蛋白质和钠的浓度分别为基线值的142%和220%。脂肪成分的变化难以解释。在第10周前观察到线性趋势，但第12周的值与断奶开始前获得的值相似。第12周时铁的浓度为基线值的172%。钙的浓度没有变化，锌的浓度在第12周降至基线值的58%。评估了营养成分浓度变化的意义、它们与乳腺 involution的关系以及哺乳期这个阶段的乳汁用于乳汁库储存的适宜性。 （注：“involution”此处可能是专业术语“退化”之类的意思，具体需结合医学专业知识准确理解）
