Krzyzowska-Gruca S, Zborek A, Gruca S
Cell Tissue Res. 1983;231(2):427-37. doi: 10.1007/BF00222192.
Female Wistar rats were injected intraperitoneally with thioacetamide or Ledakrin (1-nitro-9/3'-dimethylpropyloamine/acridine . 2 HCl) to provoke chromatin decondensation or condensation, respectively. Liver nuclei of each experimental group were used to isolate nuclear matrices. The results provide evidence that interchromatin granules are components of the nuclear matrix obtained by the procedure used in these experiments. They also reveal that the general ultrastructural pattern of the nuclear matrix is related to the degree of chromatin condensation in the nuclei used for its isolation. The distribution of interchromatin granules characteristic for the source nuclei is maintained in the nuclear matrices.
给雌性Wistar大鼠腹腔注射硫代乙酰胺或乐达君（1-硝基-9/3'-二甲基丙胺/吖啶·2盐酸盐），分别诱导染色质去浓缩或浓缩。使用每组实验大鼠的肝细胞核来分离核基质。结果表明，在这些实验所采用的方法中，染色质间颗粒是所获得核基质的组成成分。结果还显示，核基质的总体超微结构模式与用于分离核基质的细胞核中染色质的浓缩程度相关。核基质中保留了源细胞核特有的染色质间颗粒分布。
