Sasaki J, Waterman M R, Buchanan G R, Cottam G L
Clin Lab Haematol. 1983;5(1):35-44. doi: 10.1111/j.1365-2257.1983.tb00494.x.
The content and composition of plasma and erythrocyte lipids from individuals having sickle cell anaemia has been determined. The plasma contains a significantly reduced content of both cholesterol and phospholipid while the ratio of cholesteryl ester to total cholesterol, the distribution of phospholipid classes, triglyceride concentration and the fatty acid content were similar to normal values. However, the free glycerol content of the plasma was eight-fold higher than normal. Erythrocyte lipids contain an elevated level of cholesterol and control levels of phospholipid content, phospholipid distribution and fatty acid content. The plasma was separated by ultracentrifugation into VLDL (density less than 1.006), LDL (1.006 less than d less than 1.063) and HDL (1.063 less than d less than 1.21). Significant decreases in cholesterol and phospholipid were observed in LDL and HDL.
已对患有镰状细胞贫血的个体的血浆和红细胞脂质的含量及组成进行了测定。血浆中胆固醇和磷脂的含量均显著降低，而胆固醇酯与总胆固醇的比率、磷脂类别的分布、甘油三酯浓度和脂肪酸含量与正常值相似。然而，血浆中的游离甘油含量比正常水平高八倍。红细胞脂质中的胆固醇水平升高，而磷脂含量、磷脂分布和脂肪酸含量处于对照水平。通过超速离心将血浆分离为极低密度脂蛋白（VLDL，密度小于1.006）、低密度脂蛋白（LDL，1.006＜d＜1.063）和高密度脂蛋白（HDL，1.063＜d＜1.21）。在低密度脂蛋白和高密度脂蛋白中观察到胆固醇和磷脂显著减少。
