Akinyanju P A, Akinyanju C O
Ann Clin Lab Sci. 1976 Nov-Dec;6(6):521-4.
Lipids, in particular phospholipids, are essential components of membrane systems, and the measurement of phospholipids and cholesterol in plasma and tissues is helpful in diagnosis. Phospholipids represent about 60 to 70% of total red cell (RBC) lipids, while about 25% is free cholesterol. Lipids in RBC are present in a dynamic state of equilibrium, and the RBC have the capacity for rapid exchange of lipids with plasma in several ways. The present study examined the cholesterol and phospholipid levels of plasma and erythrocytes in male patients with sickle cell anemia and in healthy male individuals of comparable age. This was performed with a view to detecting possible differences that might be related to some of the RBC abnormalities which accompany the disease. The results show that plasma lipids are significantly reduced in patients with sickle cell anemia and that RBC cholesterol was higher in sickle cell patients than in normal subjects.
脂质，尤其是磷脂，是膜系统的重要组成部分，血浆和组织中磷脂和胆固醇的测量有助于诊断。磷脂约占红细胞（RBC）总脂质的60%至70%，而约25%是游离胆固醇。红细胞中的脂质处于动态平衡状态，红细胞能够通过多种方式与血浆快速交换脂质。本研究检测了镰状细胞贫血男性患者和年龄相仿的健康男性个体的血浆和红细胞中的胆固醇和磷脂水平。这样做是为了检测可能与该疾病伴随的一些红细胞异常相关的差异。结果表明，镰状细胞贫血患者的血浆脂质显著降低，且镰状细胞患者的红细胞胆固醇高于正常受试者。
