Miyamoto H, Walker J E, Ginsberg A H, Burks J S, McIntosh K, Kempe C H
Arch Neurol. 1976 Jun;33(6):414-7. doi: 10.1001/archneur.1976.00500060020005.
A virologic comparison was made of 144 patients with multiple sclerosis, 34 of their healthy siblings, and 40 patients with other neurologic diseases (OND). Antibodies in serum and cerebrospinal fluid (CSF) to vaccinia and measles viruses were measured, and these were correlated in the multiple sclerosis patients with the clinical characteristics of their disease. The CSF antibody to vaccinia virus was more frequent and at a higher titer in multiple sclerosis patients than in either control group. Moreover, a statistically significant increase was found in both frequency and titer of CSF vaccinia antibody in patients with the progressive form of the disease as compared with those classified as relapsing-remitting. Statistically significant differences between multiple sclerosis patients and their siblings were not observed for CSF or serum measles virus antibody, although both groups had significantly higher serum antibody titers than patients with OND.
对144例多发性硬化症患者、34名他们的健康同胞以及40例患有其他神经系统疾病（OND）的患者进行了病毒学比较。检测了血清和脑脊液（CSF）中针对牛痘病毒和麻疹病毒的抗体，并将多发性硬化症患者的这些抗体与其疾病的临床特征进行了关联分析。与两个对照组相比，多发性硬化症患者脑脊液中针对牛痘病毒的抗体更常见且滴度更高。此外，与复发缓解型患者相比，疾病进展型患者脑脊液中牛痘抗体的频率和滴度均有统计学意义的增加。虽然多发性硬化症患者及其同胞的脑脊液或血清麻疹病毒抗体滴度均显著高于OND患者，但两组之间未观察到统计学显著差异。
