Elling H, Ungemach F R
J Cancer Res Clin Oncol. 1983;105(3):231-7. doi: 10.1007/BF00395750.
Fifty-nine canine mammary tumors have been simultaneously assayed for their histological nature and their content of cytosolic receptors for estradiol (ER), progesterone (PGR), and dihydrotestosterone (DHTR). The tumors were histologically defined as benign tumors, malignant mixed tumors, sarcomas, and simple or complex carcinomas. The tumors exhibited a high incidence of steroid receptors (ER in 61% of the tumors, PGR in 69%, DHTR in 36%). It could be demonstrated that, in cytosols of canine mammary tumors, binding sites for different steroids may simultaneously occur. Twenty four percent of the tumors were able to bind specifically all three hormones tested. No tumor class displayed a specific receptor profile in regard to the receptor incidence, KD, and binding capacity. Also no correlation could be detected between histological grading of carcinomas and receptor incidence. In these tumors, however, the amount of ER and PGR binding showed changes dependent on differentiation. Noteworthy tumors simultaneously removed from the same bitch and with identical histological diagnosis were different in their receptor characteristics.
对59个犬乳腺肿瘤同时进行了组织学性质分析以及雌二醇（ER）、孕酮（PGR）和双氢睾酮（DHTR）胞质受体含量检测。这些肿瘤在组织学上被定义为良性肿瘤、恶性混合瘤、肉瘤以及单纯性或复杂性癌。肿瘤显示出较高的类固醇受体发生率（61%的肿瘤有ER，69%有PGR，36%有DHTR）。可以证明，在犬乳腺肿瘤的胞质溶胶中，不同类固醇的结合位点可能同时存在。24%的肿瘤能够特异性结合所有三种检测激素。就受体发生率、解离常数（KD）和结合能力而言，没有任何肿瘤类别呈现出特定的受体特征。在癌的组织学分级与受体发生率之间也未检测到相关性。然而，在这些肿瘤中，ER和PGR结合量显示出依赖于分化的变化。值得注意的是，从同一只母犬身上同时切除且组织学诊断相同的肿瘤，其受体特征却有所不同。
