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通过气相色谱-质谱联用技术鉴定色素沉着性黑色素瘤细胞培养上清液中的三种吲哚类化合物。

Identification of three indolic compounds in a pigmented-melanoma cell-culture supernatant by gas chromatography-mass spectrometry.

作者信息

Pavel S, Muskiet F A, de Ley L, The T H, van der Slik W

出版信息

J Cancer Res Clin Oncol. 1983;105(3):275-9. doi: 10.1007/BF00395758.

DOI:10.1007/BF00395758
PMID:6853590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12253483/
Abstract

In the supernatant of melanoma cell culture SK mel 25 three indolic compounds - 5-hydroxy-6-methoxyindole, 5-hydroxy-6-methoxyindolyl-2-carboxylic, and 6-hydroxy-5-methoxyindolyl-2-carboxylic acids - have been identified. The supernatants were extracted with ethyl acetate, derivatized, and analyzed by gas chromatography-mass spectrometry. The significance of this finding is discussed.

摘要

在黑色素瘤细胞系SK mel 25的培养上清液中，已鉴定出三种吲哚类化合物——5-羟基-6-甲氧基吲哚、5-羟基-6-甲氧基吲哚-2-羧酸和6-羟基-5-甲氧基吲哚-2-羧酸。用乙酸乙酯对上清液进行萃取、衍生化处理，然后通过气相色谱-质谱联用仪进行分析。本文对这一发现的意义进行了讨论。

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本文引用的文献

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O-Methylation in the conversion of tyrosine to melanin.酪氨酸转化为黑色素过程中的O-甲基化。
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Identification of two Thormählen-positive compounds from melanotic urine by gas chromatography-mass spectrometry.通过气相色谱-质谱联用技术从黑色尿中鉴定出两种托姆ählen阳性化合物。
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Eumelanin (precursor) metabolites as markers for pigmented malignant melanoma: a preliminary report.
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A qualitative gas chromatographic analysis of substituted 5,6-dihydroxyindoles from the urine of patients with melanoma.对黑素瘤患者尿液中取代的5,6 - 二羟基吲哚的定性气相色谱分析。
Tumori. 1981 Aug;67(4):325-32. doi: 10.1177/030089168106700409.
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7
Identification of two new metabolites in melanoma urine: 5-hydroxy-6-methoxyindole-2-carboxylic and 5-methoxy-6-hydroxyindole-2-carboxylic acids.在黑色素瘤尿液中鉴定出两种新代谢物：5-羟基-6-甲氧基吲哚-2-羧酸和5-甲氧基-6-羟基吲哚-2-羧酸。
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Experientia. 1965 May 15;21(5):265-6. doi: 10.1007/BF02297017.
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5,6-Dihydroxyindole is a melanin precursor showing potent cytotoxicity.5,6-二羟基吲哚是一种具有强大细胞毒性的黑色素前体。
Nature. 1978 Dec 7;276(5688):626-8. doi: 10.1038/276627a0.