Ogawa T, Suruga K, Kojima Y, Kitahara T, Kuwabara N
J Pediatr Surg. 1983 Apr;18(2):131-5. doi: 10.1016/s0022-3468(83)80533-8.
1,4-phenylenediisothiocyanate was given to five groups of rats of different developmental stages (97 in all), and the changes in the hepatobiliary system were compared histopathologically. Three groups of rats given the drug after birth showed dilatation of the extrahepatic bile ducts with inflammation. Two groups given the drug during the fetal period or added after birth showed stenotic or atretic extrahepatic bile ducts due to thickening and fibrosis of the wall. This experimental model suggests that differences in the pathologic features of infantile obstructive cholangiopathy (biliary atresia, neonatal hepatitis, and bile duct dilatation) may be the result of various developmental stages in the pathogenic process. After the experiment, 11 cases of correctable type biliary atresia were compared to 24 cases of noncorrectable type in various aspects. It is suggested that the correctable type may have suffered pathogenic process later in the developmental stages than noncorrectable type.
将1,4 - 苯二异硫氰酸酯给予五组处于不同发育阶段的大鼠（共97只），并对肝胆系统的变化进行组织病理学比较。出生后给予该药物的三组大鼠出现肝外胆管扩张并伴有炎症。在胎儿期给予该药物或出生后添加药物的两组大鼠，由于胆管壁增厚和纤维化，出现肝外胆管狭窄或闭锁。该实验模型表明，婴儿阻塞性胆管病（胆管闭锁、新生儿肝炎和胆管扩张）病理特征的差异可能是致病过程中不同发育阶段的结果。实验后，对11例可矫正型胆管闭锁病例与24例不可矫正型病例在各个方面进行了比较。结果表明，可矫正型可能比不可矫正型在发育阶段后期才遭受致病过程。
