运动训练可改善冠心病患者的脂蛋白脂质谱。

Exercise training improves lipoprotein lipid profiles in patients with coronary artery disease.

作者信息

Heath G W, Ehsani A A, Hagberg J M, Hinderliter J M, Goldberg A P

出版信息

Am Heart J. 1983 Jun;105(6):889-95. doi: 10.1016/0002-8703(83)90385-x.

Abstract

The effects of endurance exercise training on plasma lipoprotein lipids were determined in 10 men, ages 46 to 62 years, with coronary artery disease (CAD). Patients maintained body weight, health-related behaviors, and stable diets throughout the program. Training was at 50% to 85% of maximal oxygen consumption (VO2 max) for 40 to 60 minutes, 3 to 5 days/week for 29 +/- 7 weeks. Training increased VO2 max (31 +/- 19%, p less than 0.001), reduced plasma cholesterol (C) (-8 +/- 4%, p less than 0.01), low-density lipoprotein-C (LDL-C) (-9 +/- 9%, p less than 0.01), and triglyceride (TG) (-13 +/- 32%, p less than 0.05) concentrations, and increased high-density lipoprotein-C (HDL-C) levels (11 +/- 13%, p less than 0.05) and HDL-C/LDL-C ratios (25 +/- 20%, p less than 0.01). Changes in LDL-C and VO2 max were correlated (r = -0.73, p +/- 0.01), while the changes in LDL-C and HDL-C each correlated inversely with pretraining lipoprotein levels (rLDL-C = -0.77, p less than 0.01; rHDL-C = -0.68, p less than 0.05). Thus potentially "antiatherogenic" benefits of exercise seem to be due to a training effect, since they correlate best with changes in VO2 max and are maximal in patients with initially low VO2 max, high LDL-C, and low HDL-C levels.

摘要

在10名年龄在46至62岁之间的冠状动脉疾病（CAD）男性患者中，研究了耐力运动训练对血浆脂蛋白脂质的影响。在整个项目过程中，患者保持体重、与健康相关的行为以及稳定的饮食。训练强度为最大耗氧量（VO2 max）的50%至85%，持续40至60分钟，每周3至5天，共进行29±7周。训练使VO2 max增加（31±19%，p<0.001），血浆胆固醇（C）降低（-8±4%，p<0.01），低密度脂蛋白胆固醇（LDL-C）降低（-9±9%，p<0.01），甘油三酯（TG）降低（-13±32%，p<0.05），高密度脂蛋白胆固醇（HDL-C）水平升高（11±13%，p<0.05），HDL-C/LDL-C比值升高（25±20%，p<0.01）。LDL-C的变化与VO2 max相关（r = -0.73，p<0.01），而LDL-C和HDL-C的变化均与训练前的脂蛋白水平呈负相关（rLDL-C = -0.77，p<0.01；rHDL-C = -0.68，p<0.05）。因此，运动潜在的“抗动脉粥样硬化”益处似乎归因于训练效果，因为它们与VO2 max的变化相关性最佳，并且在初始VO2 max低、LDL-C高和HDL-C水平低的患者中最为明显。