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主动脉骑跨栓子。二十年经验。

Aortic saddle embolus. A twenty-year experience.

作者信息

Busuttil R W, Keehn G, Milliken J, Paredero V M, Baker J D, Machleder H I, Moore W S, Barker W F

出版信息

Ann Surg. 1983 Jun;197(6):698-706. doi: 10.1097/00000658-198306000-00008.

Abstract

Clinical experience with aortic saddle embolus (ASE) is not extensive due to the relative infrequent lodging of emboli at the aortic bifurcation. During the period 1962-1982, 26 patients (mean age, 56 years) were treated at the UCLA Medical Center for ASE and followed from 2 to 158 months (mean, 45 months). These cases were reviewed in order to identify features of diagnosis, anticoagulation, and operation which impact on results. All 26 patients presented with bilateral lower extremity ischemia with or without extension of clot to the iliac bifurcation. Ninety-six per cent of emboli were of cardiac origin and one-third occurred in patients who had previous symptoms of chronic lower extremity ischemia. Rest pain and motor/sensory deficits were main complaints in 92% of the patients, but did not become manifest until more than 6 hours, unlike more distal emboli which have an earlier presentation. Preoperative angiography, even in the patient with a history of claudication, has a small role in planning the surgical approach to patients with ASE and, although performed in 11 patients, it influenced operation in only two. Operation within the "golden period" of 6 hours after embolization did not significantly influence outcome after ASE, since 20 patients were operated on more than 6 hours after embolization, with results similar to six patients who were operated on less than 6 hours after embolization. Early high-dose heparinization, used in all patients and maintained for a mean of 12 days, may have contributed to this effect. In 22 patients (85%) Forgarty catheter extraction via bilateral groin approaches was used with a mortality of 14%; only one death was directly attributed to the catheter embolectomy. In 15% of patients, a direct approach on the aorta was selected with a zero mortality rate. Postoperative functional result was excellent with an amputation rate of only 2% (one limb). Re-embolization occurred in seven patients (27%) after discharge, five of whom had not been maintained on Coumadin and two who were not anticoagulated adequately. The authors conclude that the keys to successful treatment of ASE include high dose heparin which is maintained through the perioperative period, embolectomy without preoperative angiography, and maintenance of long-term oral anticoagulation.

摘要

由于栓子在主动脉分叉处相对较少停留,主动脉鞍状栓子(ASE)的临床经验并不丰富。在1962年至1982年期间,26例患者(平均年龄56岁)在加州大学洛杉矶分校医学中心接受了ASE治疗,并随访了2至158个月(平均45个月)。对这些病例进行回顾,以确定影响结果的诊断、抗凝和手术特征。所有26例患者均出现双侧下肢缺血,伴或不伴有血栓延伸至髂总动脉分叉处。96%的栓子起源于心脏,三分之一发生在有慢性下肢缺血既往症状的患者中。92%的患者主要症状为静息痛和运动/感觉障碍,但直到6小时以上才出现,这与更远端的栓子较早出现不同。术前血管造影,即使是有间歇性跛行病史的患者,在规划ASE患者的手术方法中作用不大,尽管11例患者进行了术前血管造影,但仅对2例手术有影响。在栓塞后6小时的“黄金期”内进行手术对ASE后的结果没有显著影响,因为20例患者在栓塞后6小时以上进行了手术,结果与6例在栓塞后6小时以内进行手术的患者相似。所有患者均使用早期大剂量肝素化,并平均维持12天,这可能有助于产生这种效果。22例患者(85%)采用经双侧腹股沟入路的Fogarty导管取栓术,死亡率为14%;只有1例死亡直接归因于导管取栓术。15%的患者选择了直接在主动脉上的手术方法,死亡率为零。术后功能结果良好,截肢率仅为2%(一条肢体)。7例患者(27%)出院后发生再栓塞,其中5例未持续服用华法林,2例抗凝不充分。作者得出结论,成功治疗ASE的关键包括在围手术期维持高剂量肝素、不进行术前血管造影的取栓术以及维持长期口服抗凝治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b52/1352896/a8a594695ad1/annsurg00136-0070-a.jpg

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