Kapp D S, Lord P F
Int J Radiat Oncol Biol Phys. 1983 Jun;9(6):917-21. doi: 10.1016/0360-3016(83)90019-6.
Thermal tolerance, that is, a reduced sensitivity to a succeeding heat treatment, has been noted in vitro and following local hyperthermia in normal tissues and malignant tumors. However, information is sparse concerning thermal tolerance following systemic hyperthermia, thereby limiting our ability to design optimally fractionated systemic hyperthermia treatment protocols. A technique for reproducibly inducing systemic hyperthermia in the rat is described, and the survival curve for rats exposed at 42.5 degrees C for periods of up to 75 minutes is presented. Using this system, increased survival of rats to systemic hyperthermia at 42.5 degrees C was demonstrated 30 hours after an initial sublethal conditioning exposure (41.8 degrees C for 1 hour). The LD50 (the time of exposure lethal to 50% of the rats) at 42.5 degrees C was increased by a factor of approximately 2 in the animals exposed to the sublethal conditioning. This increase in LD50 demonstrates the development of thermal tolerance to killing by whole body hyperthermia.
热耐受性，即对后续热处理的敏感性降低，已在体外以及正常组织和恶性肿瘤局部热疗后被观察到。然而，关于全身热疗后的热耐受性的信息却很少，这限制了我们设计最佳分次全身热疗治疗方案的能力。本文描述了一种在大鼠中可重复诱导全身热疗的技术，并给出了在42.5摄氏度下暴露长达75分钟的大鼠的存活曲线。使用该系统，在初始亚致死预处理暴露（41.8摄氏度，1小时）30小时后，证明大鼠对42.5摄氏度全身热疗的存活率有所提高。在接受亚致死预处理的动物中，42.5摄氏度时的LD50（对50%的大鼠致死的暴露时间）增加了约2倍。LD50的这种增加表明对全身热疗致死产生了热耐受性。
