Hill P, Haley N J, Wynder E L
J Chronic Dis. 1983;36(6):439-49. doi: 10.1016/0021-9681(83)90136-4.
Measurement of the absorption of cigarette smoke constituents were compared with self-reported daily consumption from 450 smokers to determine the most reliable dose dependent indicator of smoke inhalation and risk for coronary heart disease. A plateau of plasma nicotine and cotinine concentration at levels above 20 cigarettes per day with a continued increase of carboxyhemoglobin and thiocyanate with increasing consumption of cigarettes occurred. Classification of smokers into groups smoking cigarettes yielding more or less than 1 mg nicotine showed that smokers of low yield brands had lower plasma levels of nicotine and cotinine, but comparable levels of carboxyhemoglobin and thiocyanate. Plasma nicotine bore no relationship to smoke inhalation, while the number of cigarettes consumed per day showed a weak correlation to smoke inhalation. Despite the lower nicotine yield of cigarettes, modification in smoking behaviour enabled the smoker to derive as much carbon monoxide and thiocyanate constituents from low and high yield cigarettes; thus counteracting the advantage of low nicotine yield brands. The relationship of these parameters to the risk of coronary heart disease is discussed.
对450名吸烟者的香烟烟雾成分吸收量测量结果与他们自我报告的每日吸烟量进行了比较，以确定最可靠的吸入烟雾剂量依赖性指标以及冠心病风险。血浆尼古丁和可替宁浓度在每日吸烟量超过20支时趋于平稳，而随着吸烟量增加，碳氧血红蛋白和硫氰酸盐水平持续上升。将吸烟者分为吸尼古丁含量高于或低于1毫克香烟的组，结果显示低尼古丁含量品牌香烟的吸烟者血浆尼古丁和可替宁水平较低，但碳氧血红蛋白和硫氰酸盐水平相当。血浆尼古丁与烟雾吸入量无关，而每日吸烟支数与烟雾吸入量呈弱相关。尽管香烟的尼古丁含量较低，但吸烟行为的改变使吸烟者从低尼古丁含量和高尼古丁含量香烟中吸入的一氧化碳和硫氰酸盐成分一样多；因此抵消了低尼古丁含量品牌香烟的优势。文中讨论了这些参数与冠心病风险的关系。
