甲型H1N1流感病毒在人体内的循环——一项血凝素抗体研究。
Recycling of H1N1 influenza A virus in man--a haemagglutinin antibody study.
作者信息
Masurel N, Heijtink R A
出版信息
J Hyg (Lond). 1983 Jun;90(3):397-402. doi: 10.1017/s0022172400029028.
Sera from people born between 1883 and 1930 and collected in 1977 were tested for the presence of HI antibodies to A/FM/1/47 (H1N1) virus and three recently (1977 and 1978) isolated influenza A-H1N1 viruses. The highest frequency of high-titred antibody to the four H1N1 viruses was detected in sera from people born in 1903-4, i.e. 42, 54, 38, and 22% had antibody against A/FM/1/47, A/Hong Kong/117/77, A/Brazil/11/78, and A/Fukushima/103/78 respectively. The birthdate groups 1896-1907 showed a higher percentage of HI antibody titres greater than or equal to 18, greater than or equal to 50, greater than or equal to 100 or greater than or equal to 1600 against the four H1N1 viruses than the birthdate groups 1907-30. This indicates the existence of an era, 1908-18, in which, apart from the H3N2 virus (1900-18), the H1N1 virus was epidemic among the human population.
对1977年收集的、出生于1883年至1930年之间的人的血清进行了检测，以确定其中是否存在针对A/FM/1/47（H1N1）病毒以及三种最近（1977年和1978年）分离出的甲型H1N1流感病毒的血凝抑制（HI）抗体。在出生于1903 - 1904年的人的血清中，检测到针对这四种H1N1病毒的高滴度抗体的频率最高，即分别有42%、54%、38%和22%的人具有针对A/FM/1/47、A/香港/117/77、A/巴西/11/78和A/福岛/103/78的抗体。与出生于1907 - 1930年的人群相比，出生于1896 - 1907年的人群针对这四种H1N1病毒的HI抗体滴度大于或等于18、大于或等于50、大于或等于100或大于或等于1600的百分比更高。这表明在1908 - 1918年存在一个时期，在此期间，除了H3N2病毒（1900 - 1918年）外，H1N1病毒也在人群中流行。
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