Mackenzie I C, Fusenig N E
J Invest Dermatol. 1983 Jul;81(1 Suppl):189s-94s. doi: 10.1111/1523-1747.ep12541093.
The role of connective tissue in facilitating and directing the growth of epithelia during adult life is uncertain. The basic processes associated with maintenance of epithelial structure and previous work concerning the role of mesenchyme in this process in the embryo and adult are reviewed. A series of experiments examining the role of connective tissue in facilitating epithelial growth and development in vitro and after transplantation in vivo is described. These confirm the requirement for dermal elements if normal structure is to be reestablished and point to the requirement of dermal, as opposed to deep, connective tissues for facilitation of the growth of adult epithelia in vivo. The in vitro experiments suggest the presence of diffusible dermally produced factors that facilitate epithelial growth.
成年期结缔组织在促进和引导上皮生长方面的作用尚不确定。本文回顾了与上皮结构维持相关的基本过程，以及先前关于间充质在胚胎和成年期此过程中作用的研究。描述了一系列实验，这些实验研究了结缔组织在体外及体内移植后促进上皮生长和发育的作用。这些实验证实，如果要重建正常结构，真皮成分是必需的，并且指出在体内促进成年上皮生长需要真皮而非深层结缔组织。体外实验表明存在由真皮产生的可扩散因子，这些因子可促进上皮生长。
