Benessiano J, Levy B, Samuel J L, Leclercq J F, Safar M, Saumont R
Pflugers Arch. 1983 Apr;397(1):70-2. doi: 10.1007/BF00585172.
Circadian changes in heart rate and heart rate variability were measured in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Electrocardiograms (ECG) were continuously recorded, over a 24 hour period from freely moving conscious rats via three small metallic subcutaneous electrodes which were positioned a week before the recording period. The findings reported here show: 1/ Mean heart rate calculated over 24 hours were lower in both strains than previously reported. This difference probably reflects the lack of anesthesia and minimal stress in the present study. 2/ The timing of the circadian variations in both strains were the same, suggesting that were both entrained to the light-dark cycle. 3/ The 24 hours mean heart rate variability was significantly higher in SHR than in WKY but in each strain it was similar throughout the 24 hours. This suggests that the vagal tone in SHR was higher by a fairly constant amount throughout the light-dark cycle.
在自发性高血压大鼠（SHR）和正常血压大鼠（WKY）中测量心率和心率变异性的昼夜变化。通过在记录期前一周放置的三个小型皮下金属电极，对自由活动的清醒大鼠在24小时内连续记录心电图（ECG）。此处报告的结果显示：1/两品系大鼠24小时计算出的平均心率均低于先前报道的值。这种差异可能反映了本研究中未使用麻醉且应激最小。2/两品系大鼠昼夜变化的时间相同，表明二者均受明暗周期的调节。3/ SHR的24小时平均心率变异性显著高于WKY，但在每个品系中，24小时内均相似。这表明在整个明暗周期中，SHR的迷走神经张力以相当恒定的幅度更高。
