Asinovskaia N K, Oksman A Ia, Kravchenko L S, Tereshin I M
Antibiotiki. 1978 Aug;23(8):731-6.
The protein composition of the nuclear membranes of the dog kidneys after intravenous infusion of amphotericin B in a dose of 3 mg/kg and sodium desoxycholate in a dose of 1.2 mg/kg for 8 days was studied. It was found that administration of amphotericin B and sodium desoxycholate was accompanied by pronounced changes in the membrane proteins. The changes were evident from a decreased content of histones in the nuclear membranes, elimination of the high molecular components, a decreased quantitative content of some fractions and appearance of low molecular bands. The effect of sodium desoxycholate on the nuclear membrane proteins was shown to be less pronounced than that of amphotericin B. The significance of the data is discussed in connection with high toxicity of polyenic antibiotics. The data provide elucidation of the causes of the nephrotoxic effect of the polyenic antibiotics.
研究了犬肾静脉注射剂量为3mg/kg的两性霉素B和剂量为1.2mg/kg的去氧胆酸钠8天后核膜的蛋白质组成。发现两性霉素B和去氧胆酸钠的给药伴随着膜蛋白的明显变化。这些变化表现为核膜中组蛋白含量降低、高分子量成分消失、某些组分的定量含量降低以及低分子量条带的出现。结果表明，去氧胆酸钠对核膜蛋白的作用不如两性霉素B明显。结合多烯类抗生素的高毒性讨论了这些数据的意义。这些数据阐明了多烯类抗生素肾毒性作用的原因。
