Asinovskaia N K, Oksman A Ia, Kravchenko L S, Tereshin I M
Biokhimiia. 1978 Nov;43(11):2043-6.
Intraveneous injection of amphotericin B significantly affects the protein composition of canine kidney nuclear membranes. Electrophoresis in polyacrylamide gel showed that injection of this antibiotic results in a considerable loss or complete disappearance of the histone fractions H1 and H4 (depending on the dose) and a decrease in the content of fraction H3 in the membrane proteins. The fractionation spectrum of other nuclear membrane proteins also shows deviations from normal. One of possible reasons for that is the increased enzymatic degradation of the proteins. It is also probable that the changes in the protein composition of nuclear membranes are due to the presence of sodium deoxycholate in the antibiotic drug and may be accounted for by the nephrotoxic effect of polyenoic antibiotics.
静脉注射两性霉素B会显著影响犬肾核膜的蛋白质组成。聚丙烯酰胺凝胶电泳显示，注射这种抗生素会导致组蛋白组分H1和H4大量缺失或完全消失（取决于剂量），并且膜蛋白中H3组分的含量降低。其他核膜蛋白的分级谱也显示出与正常情况的偏差。其中一个可能的原因是蛋白质的酶促降解增加。核膜蛋白质组成的变化也可能是由于抗生素药物中存在脱氧胆酸钠，并且可能是由多烯类抗生素的肾毒性作用引起的。
