人类新生儿肾素和醛固酮对血容量急性变化的反应。
Renin and aldosterone response in human newborns to acute change in blood volume.
作者信息
Dillon M J, Rajani K B, Shah V, Ryness J M, Milner R D
出版信息
Arch Dis Child. 1978 Jun;53(6):461-7. doi: 10.1136/adc.53.6.461.
Increased activity of the renin/aldosterone system in the neonatal period is now well established in both animals and man but the control mechanisms are poorly understood. We have monitored the plasma renin activity (PRA) and plasma aldosterone concentration (PAldo) in 14 infants undergoing 21 exchange transfusions. PRA and PAldo were measured before and at 5, 10, 15, 30, 45, and 60 minutes after the injection, and 5, 10, 15, and 30 minutes after the withdrawal of 7 ml blood/kg birthweight immediately before exchange transfusions. PRA increased to a maximum of 53% and decreased to a maximum of 39% of the resting values after withdrawal or injection of blood respectively. PAldo values did not change significantly during the same period. Thus the renin-angiotensin system in the newborn infant is responsive to changes in blood volume.
新生儿期肾素/醛固酮系统活性增加在动物和人类中都已得到充分证实，但对其控制机制了解甚少。我们监测了14名接受21次换血治疗的婴儿的血浆肾素活性（PRA）和血浆醛固酮浓度（PAldo）。在注射前、注射后5、10、15、30、45和60分钟以及在换血前立即抽取7ml/kg出生体重的血液后5、10、15和30分钟测量PRA和PAldo。分别在抽血或注射后，PRA最高增加至静息值的53%，最低降至静息值的39%。在此期间，PAldo值无显著变化。因此，新生儿的肾素-血管紧张素系统对血容量变化有反应。
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