Singh S P, Mehra N K, Dingley H B, Pande J N, Vaidya M C
Tissue Antigens. 1983 May;21(5):380-4. doi: 10.1111/j.1399-0039.1983.tb00187.x.
Investigations for the HLA-A, -B, -C and -DR antigens were conducted on 124 random North Indian patients with confirmed diagnosis of pulmonary tuberculosis by the demonstration of acid fast bacilli in the sputum. 109 appropriately matched controls from the same ethnic background were also tissue typed. No significant deviation was observed in the HLA-A, -B, and -C locus antigens. With the HLA-DR typing, there was a marginal increase in DR2 and a concurrent significant decrease in DRw6 in the patient group. These deviations were, however, insignificant when correction for the P value was made. ABO blood group typing results indicate that blood group 'O' may afford protection against TB. The involvement of both DR2 and DRw6 is interesting as it is also implicated in leprosy, another mycobacterial disease. The results suggest the possibility of a common gene in the MHC for both tuberculosis and leprosy.
对124名经痰涂片抗酸杆菌检查确诊为肺结核的北印度随机患者进行了HLA - A、- B、- C和 - DR抗原检测。还对109名来自相同种族背景的匹配对照进行了组织分型。在HLA - A、- B和 - C位点抗原方面未观察到显著偏差。对于HLA - DR分型，患者组中DR2略有增加，同时DRw6显著减少。然而，在对P值进行校正后，这些偏差并不显著。ABO血型分型结果表明，“O”型血可能对结核病有保护作用。DR2和DRw6都与之相关很有意思，因为它们也与另一种分枝杆菌病麻风病有关。结果提示在主要组织相容性复合体（MHC）中可能存在结核病和麻风病的共同基因。
