蛋白质分子中螺旋结构的低频振动。
Low-frequency vibrations of helical structures in protein molecules.
作者信息
Chou K C
出版信息
Biochem J. 1983 Mar 1;209(3):573-80. doi: 10.1042/bj2090573.
Abstract
A physically intuitive and mathematically easily handled formula is presented for calculating the low-frequency vibrations of helical structures in protein molecules. alpha-Chymotrypsin is taken as an example, and the calculated result shows precise agreement with observations of the low-frequency Raman spectra. As reflected in the formula, this kind of low frequency is very sensitive to the conformation of a biomacromolecule, and can therefore serve as a vehicle to investigate the mechanism of action of a biomacromolecule from the viewpoint of dynamics. On this basis a feasible experiment is suggested by which one can examine the relationship between a presumed mode of low-frequency vibration in a biomacromolecule and its activity.
摘要
本文提出了一个基于物理直观性且数学上易于处理的公式，用于计算蛋白质分子中螺旋结构的低频振动。以α-胰凝乳蛋白酶为例，计算结果与低频拉曼光谱的观测结果精确吻合。正如公式所反映的，这种低频对生物大分子的构象非常敏感，因此可以作为从动力学角度研究生物大分子作用机制的一种手段。在此基础上，提出了一个可行的实验，通过该实验可以研究生物大分子中假定的低频振动模式与其活性之间的关系。
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Application of a Theory of Enzyme Specificity to Protein Synthesis.酶特异性理论在蛋白质合成中的应用。
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