针对大鼠肉瘤的单克隆抗体。II. 具有抗肿瘤活性的同基因IgG2b抗体。
Monoclonal antibodies to rat sarcomata. II. A syngeneic IgG2b antibody with anti-tumour activity.
作者信息
North S M, Dean C J
出版信息
Immunology. 1983 Aug;49(4):667-71.
Abstract
The IgG2b monoclonal antibody M10/76, which is specific for the Hooded rat fibrosarcoma MC24, was obtained by fusion of the rat myeloma Y3 Ag 1.2.3 with spleen cells from an MC24 tumour-bearing rat. This antibody has been found to inhibit lung colonization when MC24 cells were injected i.v. into Hooded rats, and when passively transferred into athymic MC24 tumour bearers, it prevented or considerably reduced the incidence of spontaneous lung metastases in more than half the treated animals.
摘要
针对 Hooded 大鼠纤维肉瘤 MC24 具有特异性的 IgG2b 单克隆抗体 M10/76，是通过大鼠骨髓瘤 Y3 Ag 1.2.3 与来自荷 MC24 肿瘤大鼠的脾细胞融合获得的。已发现，当将 MC24 细胞静脉注射到 Hooded 大鼠体内时，该抗体可抑制肺部定植；而当将其被动转移至无胸腺的 MC24 肿瘤荷瘤大鼠体内时，在超过半数的受试动物中，它可预防或显著降低自发性肺转移的发生率。
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