Eccles S A, Heckford S E, Alexander P
Br J Cancer. 1980 Aug;42(2):252-9. doi: 10.1038/bjc.1980.224.
Cyclosporin A (Cy A), a novel immunosuppressive agent with apparently selective inhibitory effects on T lymphocytes and little myelotoxicity, was tested for its effects on a variety of syngeneic animal tumours including sarcomas, carcinomas and a T-cell lymphoma. Cy A, given orally or parenterally in repeated doses, had no effect on the growth rates of any of the tumours tested, but a highly significant effect on metastasis was seen in many cases. All the sarcomas examined in both rats and mice, and also the lymphoma, showed a marked increase in their metastases, in some cases even when administration of Cy A was delayed until after excision of the "primary" tumour implants. In contrast no effect of Cy A on metastasis was observed in animals bearing poorly immunogenic mammary or squamous-cell carcinomas. The metastases developing in Cy A-treated animals, when transplanted into normal syngeneic animals, showed no evidence of enhanced metastatic potential compared with their "parent tumours.
环孢菌素A（Cy A）是一种新型免疫抑制剂，对T淋巴细胞具有明显的选择性抑制作用，且骨髓毒性较小。我们测试了它对多种同基因动物肿瘤的作用，包括肉瘤、癌和一种T细胞淋巴瘤。重复口服或非肠道给予Cy A，对所测试的任何肿瘤的生长速率均无影响，但在许多情况下对转移有高度显著的影响。在大鼠和小鼠中检查的所有肉瘤以及淋巴瘤，其转移均显著增加，在某些情况下，即使将Cy A的给药延迟至“原发性”肿瘤植入物切除后也是如此。相比之下，在携带免疫原性较差的乳腺癌或鳞状细胞癌的动物中，未观察到Cy A对转移有影响。将经Cy A处理的动物中发生的转移瘤移植到正常同基因动物中时，与它们的“亲本肿瘤”相比，没有显示出转移潜能增强的迹象。
