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Immunology. 1987 Feb;60(2):181-6.
2
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THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
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Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host.在原发性本地宿主中对甲基胆蒽诱导的肉瘤产生抗性的证明。
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The biological half-lives of four rat immunoglobulin isotypes.四种大鼠免疫球蛋白同种型的生物学半衰期。
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4
Monoclonal antibodies to rat sarcomata. I. Immunization procedures and source of lymphoid cells for hybridoma production.针对大鼠肉瘤的单克隆抗体。I. 杂交瘤生产的免疫程序及淋巴细胞来源
Immunology. 1982 Nov;47(3):397-405.
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Suppression of tumor rejection by autologous anti-idiotypic immunity.自体抗独特型免疫对肿瘤排斥反应的抑制作用。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2209-13. doi: 10.1073/pnas.77.4.2209.
6
Altered tumor growth in vivo after immunization of mice with antitumor antibodies.用抗肿瘤抗体免疫小鼠后，其体内肿瘤生长发生改变。
Cancer Res. 1984 Aug;44(8):3291-8.
7
Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice.通过在小鼠体内施用抗独特型抗体诱导对人肿瘤标志物的免疫。
Proc Natl Acad Sci U S A. 1984 May;81(9):2864-7. doi: 10.1073/pnas.81.9.2864.
8
Subclass restriction of the antiidiotypic antibody response in the rat.
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9
Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient?癌症患者体内的人抗独特型抗体：免疫反应的调节对患者有益吗？
Proc Natl Acad Sci U S A. 1984 Jan;81(1):216-9. doi: 10.1073/pnas.81.1.216.
10
Neonatal administration of idiotype or antiidiotype primes for protection against Escherichia coli K13 infection in mice.新生小鼠接种独特型或抗独特型可引发对大肠杆菌K13感染的保护作用。
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用同基因单克隆抗独特型抗体进行疫苗接种可抵御肿瘤攻击。

Vaccination with syngeneic monoclonal anti-idiotype protects against a tumour challenge.

作者信息

Dunn P L, Johnson C A, Styles J M, Pease S S, Dean C J

出版信息

Immunology. 1987 Feb;60(2):181-6.

PMID:3817870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453237/
Abstract

Rat X rat hybridomas secreting monoclonal anti-idiotypic antibodies have been prepared from Hooded rats immunized with two tumour-reactive, syngeneic monoclonal antibodies 11/160 and M10/76 (specific, respectively, for the Hooded rat sarcomata HSN and MC24). The hybridomas were selected on the basis that the secreted antibodies competed with antigen for binding to the immunizing idiotype. One monoclonal anti-idiotype (HIM/1/230, gamma 2a isotype) that recognizes an antigen-binding site idiotope of antibody 11/160 has been found to substitute for antigen. Hooded rats vaccinated by three challenges with HIM/1/230 produce serum Ab3 that is indistinguishable in antigen specificity from the 11/160 Ab1, and show reduced tumour take following an i.v. challenge with 10(6) HSN cells. The response to vaccination with anti-idiotype was both qualitatively and quantitatively dependent on the mode of immunization. High titre 11/160-like Ab3 was generated only when the vaccine contained Freund's adjuvant, whereas resistance to tumour challenge was found only in animals vaccinated with anti-idiotype in the absence of adjuvant.

摘要

用两种肿瘤反应性同基因单克隆抗体11/160和M10/76（分别对帽状大鼠肉瘤HSN和MC24具有特异性）免疫帽状大鼠后，制备了分泌单克隆抗独特型抗体的大鼠×大鼠杂交瘤。基于分泌的抗体与抗原竞争结合免疫原性独特型来选择杂交瘤。已发现一种识别抗体11/160抗原结合位点独特型的单克隆抗独特型抗体（HIM/1/230，γ2a同种型）可替代抗原。用HIM/1/230进行三次免疫的帽状大鼠产生的血清Ab3在抗原特异性上与11/160 Ab1无法区分，并且在静脉注射10⁶个HSN细胞进行攻击后肿瘤接种率降低。对抗独特型疫苗接种的反应在质量和数量上均取决于免疫方式。仅当疫苗含有弗氏佐剂时才产生高滴度的11/160样Ab3，而仅在无佐剂情况下用抗独特型疫苗接种的动物中发现对肿瘤攻击的抗性。