Singh I, Kishimoto Y
J Lipid Res. 1983 May;24(5):662-5.
alpha-Cyclodextrin at concentrations of 1-8 mM helps dissolve, in aqueous solution, fatty acids such as lignoceric, stearic, and palmitic, and complex lipids such as ceramide and cerebroside that contain these acids. Formation of an inclusion complex was indicated on examination of the solution by gel filtration. alpha-Cyclodextrin strikingly increased synthesis of ceramide from sphingosine and either free lignoceric or stearic acid by rat brain preparations. These results suggest the further use of alpha-cyclodextrin in lipid enzymology, especially in relation to sphingolipid metabolism.
浓度为1 - 8 mM的α-环糊精有助于在水溶液中溶解木蜡酸、硬脂酸和棕榈酸等脂肪酸，以及含有这些酸的神经酰胺和脑苷脂等复合脂质。通过凝胶过滤检查溶液表明形成了包合物。α-环糊精显著增加了大鼠脑制剂从鞘氨醇与游离木蜡酸或硬脂酸合成神经酰胺的量。这些结果表明α-环糊精在脂质酶学中，特别是与鞘脂代谢相关方面有进一步应用。
