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阿霉素外渗：皮肤和软组织损伤的外科治疗及可能的预防措施

Adriamycin extravasation: surgical treatment and possible prevention of skin and soft-tissue injuries.

作者信息

Pitkänen J, Asko-Seljavaara S, Gröhn P, Sundell B, Heinonen E, Appelqvist P

出版信息

J Surg Oncol. 1983 Aug;23(4):259-62. doi: 10.1002/jso.2930230409.

DOI:10.1002/jso.2930230409
PMID:6876801
Abstract

In a material consisting of approximately 6,000 injections of Adriamycin during a 2-year period, eleven moderate and five severe extravasation injuries have been observed. Even a small leakage of the drug may cause a permanent lesion. The most serious injuries were caused by large doses and on the dorsum of the hand. Plastic surgical operations were successfully performed in the severe cases. An active surgical intervention after primary neutralization of the extravasated Adriamycin is recommended.

摘要

在一个两年期间内约有6000次阿霉素注射的材料中，观察到11例中度和5例重度外渗损伤。即使药物少量渗漏也可能导致永久性损伤。最严重的损伤是由大剂量药物和手部背部注射引起的。严重病例成功进行了整形手术。建议在对渗漏的阿霉素进行初步中和后进行积极的手术干预。

相似文献

1
Adriamycin extravasation: surgical treatment and possible prevention of skin and soft-tissue injuries.阿霉素外渗：皮肤和软组织损伤的外科治疗及可能的预防措施
J Surg Oncol. 1983 Aug;23(4):259-62. doi: 10.1002/jso.2930230409.
2
Adriamycin extravasation.阿霉素外渗
Plast Reconstr Surg. 1978 Jan;61(1):86-92. doi: 10.1097/00006534-197801000-00015.
3
Prevention of extravasation injuries secondary to doxorubicin.预防阿霉素所致的外渗性损伤。
Postgrad Med. 1985 Mar;77(4):105-9, 112, 114. doi: 10.1080/00325481.1985.11698920.
4
Recall phenomenon or severe skin and muscle necrosis following Adriamycin extravasation in the hand.手部阿霉素外渗后的回忆现象或严重皮肤及肌肉坏死。
Int Surg. 1984 Jan-Mar;69(1):73-4.
5
Treatment of extensive avulsions of skin and subcutaneous tissues.
J Dermatol Surg Oncol. 1978 Apr;4(4):322-7. doi: 10.1111/j.1524-4725.1978.tb00436.x.
6
Surgical management of doxorubicin (Adriamycin) extravasation.阿霉素（多柔比星）外渗的外科处理
J Pediatr Orthop. 1984 Jan;4(1):96-9. doi: 10.1097/01241398-198401000-00018.
7
Skin ulcers due to adriamycin.
Cancer. 1976 Sep;38(3):1087-94. doi: 10.1002/1097-0142(197609)38:3<1087::aid-cncr2820380308>3.0.co;2-x.
8
Management of extensive doxorubicin hydrochloride extravasation injuries.广泛型盐酸多柔比星外渗损伤的处理
J Hand Surg Am. 1983 Jan;8(1):32-8. doi: 10.1016/s0363-5023(83)80048-3.
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Protection against adriamycin-induced skin necrosis in the rat by dimethyl sulfoxide and alpha-tocopherol.二甲基亚砜和α-生育酚对阿霉素诱导的大鼠皮肤坏死的保护作用。
Cancer Res. 1981 Sep;41(9 Pt 1):3395-9.
10
[A patient with a severe injury of the back of the hand following extravasation of doxorubicin].
Ned Tijdschr Geneeskd. 1984 Mar 31;128(13):603-6.

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