Sawada T, Hirohata S, Inoue T, Ito K
Department of Medicine and Physical Therapy, University of Tokyo School of Medicine, Japan.
Clin Exp Rheumatol. 1991 Jul-Aug;9(4):363-8.
Synovial fluids (SF) and sera (S) from patients with rheumatoid arthritis (RA) were examined for IgM, IgM-rheumatoid factor (IgM-RF), albumin and interleukin-6 (IL-6) activity. The quotient of SF/S IgM-RF was elevated compared with that of SF/S albumin in 7 patients with seropositive RA, although the quotient of SF/S IgM was lower than that of SF/S albumin. SF IL-6 activity was much higher than serum IL-6 activity in all the 7 RA patients. In synovial fluids from 22 seropositive RA patients, SF IL-6 activity was significantly correlated with the SF IgM-RF, IgG-RF and IgA- less than RF, but not with SF IgM, IgG or IgA. Moreover, SF IgM-RF as well as SF IL-6 activity was significantly correlated with the Westergren erythrocyte sedimentation rate (ESR) or the Lansbury articular index. These results indicate that IL-6 and RF might be produced within the rheumatoid joints as a result of abnormal immune system activation, which is associated with the disease activity of RA. Three of the 4 seronegative RA patients, however, showed high SF IL-6 without detectable levels of SF IgM-RF, indicating that IL-6 alone is not sufficient for IgM-RF production.
对类风湿性关节炎（RA）患者的滑液（SF）和血清（S）进行了IgM、IgM类风湿因子（IgM-RF）、白蛋白和白细胞介素-6（IL-6）活性检测。在7例血清阳性RA患者中，SF/S IgM-RF的比值高于SF/S白蛋白的比值，尽管SF/S IgM的比值低于SF/S白蛋白的比值。在所有7例RA患者中，滑液IL-6活性远高于血清IL-6活性。在22例血清阳性RA患者的滑液中，滑液IL-6活性与滑液IgM-RF、IgG-RF和IgA-RF呈显著相关，但与滑液IgM、IgG或IgA无关。此外，滑液IgM-RF以及滑液IL-6活性与魏氏血沉率（ESR）或兰斯伯里关节指数显著相关。这些结果表明，IL-6和RF可能是由于免疫系统异常激活在类风湿关节内产生的，这与RA的疾病活动相关。然而，4例血清阴性RA患者中有3例滑液IL-6水平较高，但未检测到滑液IgM-RF水平，这表明仅IL-6不足以产生IgM-RF。
