Caldwell E H, Stewart S
Plast Reconstr Surg. 1983 Aug;72(2):231-3. doi: 10.1097/00006534-198308000-00022.
Skin necrosis secondary to Coumadin-congener therapy is a rare, unpredictable complication. A case is reported of a patient given sodium warfarin therapy following coronary artery bypass who developed skin necrosis of the trochanteric region, bilaterally, and the right breast on the fourth day following administration of Coumadin. The Coumadin therapy was discontinued, and the areas of skin necrosis went on to slow, spontaneous healing. However, significant subcutaneous induration persisted, although the areas were no longer painful.
香豆素类药物治疗继发的皮肤坏死是一种罕见且不可预测的并发症。本文报告了一例冠状动脉搭桥术后接受华法林钠治疗的患者，在服用香豆素类药物后的第四天，双侧转子区及右侧乳房出现皮肤坏死。香豆素类药物治疗被停用，皮肤坏死区域逐渐缓慢自愈。然而，尽管这些区域不再疼痛，但仍存在明显的皮下硬结。
