Konno H, Kubota T, Tsuyuki K, Nakada M, Kubouchi K, Yoshizumi Y, Asanuma F, Kurihara H, Koh J, Ishibiki K, Abe O
Gan To Kagaku Ryoho. 1983 Mar;10(3):775-80.
Influences of natural killer cells on the transplantable human tumors was evaluated by using anti-asialo GM1 antibody. Two human gastric adenocarcinomas designated as St-4 (poorly differentiated) and St-40 (well differentiated) were inoculated into nude mice. The effects of anti-asialo GM1 antibody were assessed in terms of tumor doubling time (Td) and 3H-thymidine (3H-TdR) uptake labeling index (L.I.). Whereas the Td of St-4 was significantly shortened by administration of anti-asialo GM1 antibody, no noticeable changes were observed in St-40. This enhanced growth of St-4 was also supported by the elevation of L.I. both in flashing and repeating methods. On the other hand, as the repeated L.I. of St-40 was almost 100% in control tumors, repeated L.I. was not increased by the administration of anti-asialo GM1 antibody. It was supported that natural killer activity of nude mice regulated the growth of transplantable human tumors concerning with the growth fractions.
通过使用抗去唾液酸GM1抗体评估自然杀伤细胞对可移植人类肿瘤的影响。将两种人胃腺癌分别命名为St-4（低分化）和St-40（高分化）接种到裸鼠体内。根据肿瘤倍增时间（Td）和3H-胸腺嘧啶核苷（3H-TdR）摄取标记指数（L.I.）评估抗去唾液酸GM1抗体的作用。给予抗去唾液酸GM1抗体后，St-4的Td显著缩短，而St-40未观察到明显变化。闪烁法和重复法中L.I.的升高也支持了St-4这种生长增强的情况。另一方面，由于对照肿瘤中St-40的重复L.I.几乎为100%，给予抗去唾液酸GM1抗体后重复L.I.并未增加。这支持了裸鼠的自然杀伤活性与生长分数相关，调节可移植人类肿瘤生长的观点。
