Chmielnicka J, Bem E M, Kaszubski P
Environ Res. 1983 Aug;31(2):266-72. doi: 10.1016/0013-9351(83)90003-8.
Four groups of rats were given: cadmium chloride (Cd), cadmium chloride and mercuric chloride (Cd + Hg), cadmium chloride and sodium selenite (Cd + Se), or cadmium chloride, mercuric chloride, and sodium selenite (Cd + Hg + Se). All animals received subcutaneous doses of 115mCdCl2 (0.3 mg Cd/kg) every other day for 2 weeks. Mercuric chloride was administered intravenously at doses of 0.5 mg Hg/kg every other day, and Na2 75SeO3 intragastrically at doses of 0.1 mg Se/kg every day for a fortnight. The whole-body and organ retention of cadmium changed slightly with the type of exposure. A significant interaction effect of the examined elements was noted in the nuclear and soluble fractions of the liver and kidneys. Mercury decreased the cadmium concentration in both the nuclear and soluble fractions of the kidneys and diminished the effect of selenium on the cadmium level in the soluble fraction of the kidneys. In the liver the presence of mercury contrary to selenium, lowered the cadmium level in the nuclear fraction. The pattern of cadmium binding to proteins of the soluble fraction of the kidneys and liver remained the same in all groups of animals.
氯化镉（Cd）、氯化镉和氯化汞（Cd + Hg）、氯化镉和亚硒酸钠（Cd + Se）、或氯化镉、氯化汞和亚硒酸钠（Cd + Hg + Se）。所有动物每隔一天皮下注射115mCdCl2（0.3毫克镉/千克），持续2周。每隔一天静脉注射0.5毫克汞/千克的氯化汞，每天经胃给予0.1毫克硒/千克的Na2 75SeO3，持续两周。镉在全身和器官中的潴留量随暴露类型略有变化。在肝脏和肾脏的核组分和可溶组分中，观察到所检测元素之间存在显著的相互作用。汞降低了肾脏核组分和可溶组分中的镉浓度，并减弱了硒对肾脏可溶组分中镉水平的影响。在肝脏中，与硒相反，汞的存在降低了核组分中的镉水平。在所有动物组中，镉与肾脏和肝脏可溶组分中蛋白质的结合模式保持不变。
